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Diclofenac Topical Gel General Information

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Diclofenac Topical Gel is used to relieve joint pain from arthritis. Diclofenac belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs).

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain.

How to Use Diclofenac Topical Gel

Read the Medication Guide and Patient Instructions for Use provided by your pharmacist before you start using diclofenac and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Diclofenac Topical Gel is for use on the skin only. To measure the right dose, use the dosing card(s) provided with the medication. Place a dosing card on a flat surface so that you can read the print on the card. Squeeze an even line of the medication from the tube onto the dosing card, using the marks on the card to measure the prescribed dose. Gently rub the medication into the entire affected joint, usually 4 times daily or as directed by your doctor. You may use the dosing card to apply the medication. Do not apply the medication on skin that has cuts, infections, or rashes.

If the package instructions direct you to reuse the dosing card, then after each use, hold the card with your fingertips, rinse, and dry. When you are ready to discard the dosing card, fold the card in half with the medication side inside and throw away out of the reach of children and pets. Wash your hands after using the medication unless you are using it to treat the hands. Do not shower, bathe, or wash any treated areas for at least an hour after applying the medication. Wait at least 10 minutes before covering the treated area with gloves or clothing. Do not wrap, bandage, or apply heat (such as a heating pad) to the treated area.

The dosage is based on your medical condition and response to treatment. Do not apply more than 16 grams of diclofenac per day to any single joint of the lower body (such as knee, ankle, foot). Do not apply more than 8 grams of diclofenac per day to any single joint of the upper body (such as hand, wrist, elbow). No matter how many joints you are treating, do not use more than a total of 32 grams of diclofenac per day.

Discuss the risks and benefits of using Diclofenac Topical Gel with your doctor or pharmacist. To reduce the risk of side effects, use Diclofenac Topical Gel at the lowest effective dose for the shortest possible time. Do not increase your dose, use it more often than prescribed, or apply the medication to any area not prescribed by your doctor.

Do not get the medication in the eyes, nose, or mouth. If you do get the medication in those areas, flush with plenty of water. Contact your doctor right away if irritation persists.

For certain conditions (such as arthritis), it may take up to 2 weeks of using Diclofenac Topical Gel regularly until you get the full benefit.

If you are using Diclofenac Topical Gel "as needed" (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your pain persists or worsens.

Diclofenac Topical Gel Possible Side Effects

Skin irritation/redness may occur at the application site. If this effect persists or worsens, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed Diclofenac Topical Gel because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Diclofenac Topical Gel do not have serious side effects.

Diclofenac Topical Gel may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: swelling ankles/feet/hands, sudden/unexplained weight gain, unusual tiredness, change in the amount of urine.

Diclofenac Topical Gel may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including: persistent nausea/vomiting, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.

A very serious allergic reaction to Diclofenac Topical Gel is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Diclofenac Topical Gel Precautions

Before using diclofenac, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, naproxen, celecoxib); or if you have any other allergies. Diclofenac Topical Gel may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using Diclofenac Topical Gel, tell your doctor or pharmacist your medical history, especially of: asthma, aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), liver disease, stomach/intestine problems (such as bleeding, ulcers), heart disease (such as previous heart attack), high blood pressure, stroke, swelling (edema, fluid retention), blood disorders (such as anemia), bleeding/clotting problems, growths in the nose (nasal polyps).

Kidney problems can sometimes occur with the use of NSAID medications, including diclofenac. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have any unusual change in the amount of urine.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Diclofenac Topical Gel may cause stomach bleeding. Daily use of alcohol and tobacco while using Diclofenac Topical Gel may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Ask your doctor or pharmacist about how much alcohol you may safely drink.

Diclofenac Topical Gel may make the treated area more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Wear protective clothing when outdoors. Ask your doctor whether you should use sunscreen along with Diclofenac Topical Gel.

Older adults may be more sensitive to the side effects of Diclofenac Topical Gel, especially stomach/intestinal bleeding, kidney problems and worsening heart problems.

Before using Diclofenac Topical Gel, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, Diclofenac Topical Gel should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

It is unknown if this form of diclofenac passes into breast milk. Consult your doctor before breast-feeding.

Diclofenac Topical Gel Possible Intercations

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with Diclofenac Topical Gel include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, corticosteroids (such as dexamethasone, prednisone), lithium, methotrexate, other products applied to treated skin, "water pills" (diuretics such as furosemide).

Diclofenac Topical Gel may increase the risk of bleeding when used with other drugs that also may cause bleeding. Examples include antiplatelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, erlotinib, among others.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as ibuprofen, naproxen, or ketorolac). These drugs are similar to diclofenac and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

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